Download Antimicrobial Resistance: Beyond the Breakpoint (Issues in by J. Todd Weber PDF

By J. Todd Weber

Fighting, controlling and treating drug-resistant infections is without doubt one of the significant demanding situations in smooth drugs. "Antimicrobial Resistance" is going past uncomplicated definitions and microbiological information to totally discover this speedily altering sector, describing facts for potent interventions, bills, therapy techniques and instructions for destiny study. every one bankruptcy offers crucial heritage and examines the proof for a big point of prevention and regulate, remedy technique or coverage determination. Prevention and keep watch over ideas are analyzed for beside the point antimicrobial use, fluoroquinolone-resistant organisms, health-care linked infections and parasitic ailments. additionally, therapy suggestions for altering resistance styles are explored for community-acquired pneumonia in the course of an influenza pandemic and infections with community-associated MRSA, extended-spectrum beta-lactamase generating organisms and fungi. information for coverage making are awarded in articles that aspect the prices of antimicrobial-resistant infections in healthcare settings and the specter of resistance with the advent of antiretroviral treatment for big populations within the constructing international. those experiences exhibit the place interventions, surveillance and examine should be most dear sooner or later. "Antimicrobial Resistance" is a useful contribution for infectious disorder physicians and public future health officers who're drawn to the prevention of antimicrobial-resistant infections.

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Extra resources for Antimicrobial Resistance: Beyond the Breakpoint (Issues in Infectious Diseases)

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JAMA 1998;280: 1233–1237. 61 Patterson JE, Hardin TC, Kelly CA, Garcia RC, Jorgensen JH: Association of antibiotic utilization measures and control of multiple-drug resistance in Klebsiella pneumoniae. Infect Control Hosp Epidemiol. 2000;21:455–458. 62 Bradford PA, Cherubin CE, Idemyor V, Rasmussen BA, Bush K: Multiply resistant Klebsiella pneumoniae strains from two Chicago hospitals: identification of the extended-spectrum TEM-12 and TEM-10 ceftazidime-hydrolyzing beta-lactamases in a single isolate.

Coli in the United States. In a point prevalence study on the skilled care floor of a Chicago nursing home, 46% of residents were colonized with ESBL-producing organisms (all E. coli) [10]. These patients had been in the nursing home, without intercurrent hospitalization, for a mean of more than 6 months. Patients from this nursing home, as well as 7 other nursing homes, served as a reservoir for introduction of ESBL-producing organisms into an acutecare hospital [10]. A variety of other organisms have been found to produce ESBLs.

Patients with invasive infections due to these strains, particularly enteric fever, respond less well to fluoroquinolones when compared with infections due to wild-type strains [13–15]. These strains are usually resistant to nalidixic acid. 125 μg/ml [16]. Similar results have been obtained for S. enterica serotype Typhi [14]. Recent guidelines have suggested that decreased susceptibility to fluoroquinolones in invasive isolates of S. enterica should be established by nalidixic acid resistance or a ciprofloxacin MIC.

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